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. 2018 Jun 21;17:96. doi: 10.1186/s12943-018-0844-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Identification of the EMT-related ceRNA regulatory network. a Flowchart of the integrative analysis. b The ceRNA network in mesenchymal OvCa. Rounded rectangles, ellipses and hexagons denote lncRNAs, EMT genes and miRNAs, respectively. The lncRNAs and EMT genes, which are shown in blue, were significantly up-regulated in mesenchymal OvCa compared with epithelial OvCa. Up-regulated miRNAs are shown in red, and down-regulated miRNAs are shown in green. c Genomic distance between lncRNAs and correlated EMT genes. SNAI2 was significantly up-regulated in mesenchymal OvCa compared with epithelial OvCa in the TCGA (d) and GSE9891 (e) data sets. Kaplan-Meier overall survival curves for OvCa patients with high and low expression of SNAI2 in the TCGA (f) and GSE9891 (g) data sets. h miR-25 was significantly down-regulated in mesenchymal OvCa compared with epithelial OvCa in the TCGA data set. The lncRNA PTAF was significantly up-regulated in mesenchymal OvCa compared with epithelial OvCa in the TCGA (i) and GSE9891 (j) data sets