FIGURE 8:

In silico removal of direct crosstalk between ATF6 and PERK pathways. (A) Schematic showing the steps targeted by in silico deletion (red “X”). (B–F) Model simulations were run after removal of the contribution of ATF6 to transcription of Chop (ΔA6→c; yellow dashed line), the contribution of ATF4 to Bip transcription (ΔA4→b; green dashed line), or both (linear; magenta dotted line). Selected model outputs for the 2.5-nM condition are shown (B–D). Panels E and F graph the ratio of CHOP to BiP during the simulation for 2.5- and 10-nM conditions, respectively.