Table 1.
Poisson regression P-values for association of biomarkers with individual ESSDAI domains
| ESSDAI domain | BAFF | β2M | FLCλ | FLCκ | ΣFLC | IgG |
|---|---|---|---|---|---|---|
| Constitutional | 2.93E-01 | 2.13E-01 | 2.93E-01 | 2.13E-01 | 2.13E-01 | 2.13E-01 |
| Lymphadenopathy | 6.71E-01 | 6.71E-01 | 6.29E-01 | 1.94E-01 | 1.94E-01 | 7.80E-01 |
| Glandular | 8.35E-01 | 4.35E-01 | 3.91E-01 | 1.74E-01 | 1.74E-01 | 1.74E-01 |
| Articular | 4.03E-01 | 7.73E-01 | 4.03E-01 | 4.03E-01 | 4.03E-01 | 9.14E-02 |
| Cutaneous | 2.15E-01 | 6.90E-04*** | 1.14E-03*** | 9.56E-06*** | 4.21E-05*** | 4.93E-03** |
| Respiratory | 1.62E-01 | 1.62E-01 | 9.33E-01 | 9.33E-01 | 9.33E-01 | 3.07E-01 |
| Muscular | 3.01E-01 | 7.99E-02 | 7.06E-01 | 3.01E-01 | 3.53E-01 | 4.14E-01 |
| Peripheral nervous system | 2.25E-05*** | 5.22E-02 | 8.90E-01 | 8.90E-01 | 8.90E-01 | 8.90E-01 |
| Haematological | 1.73E-01 | 1.73E-01 | 5.91E-01 | 4.28E-01 | 4.50E-01 | 5.91E-01 |
| Biological | 5.97E-01 | 2.94E-15*** | 5.03E-29*** | 1.32E-35*** | 9.84E-36*** | 2.00E-49*** |
| Renal | 1.57E-01 | 3.71E-16*** | 1.43E-09*** | 1.01E-10*** | 8.38E-11*** | 7.07E-02 |
CNS domain excluded since only two patients active.
**
P < 0.01.
***
P < 0.001. BAFF: B cell activating factor; β2M: β-2 microglobulin; FLC: free light chain.