Skip to main content
. 2018 Feb 10;114(8):1178–1188. doi: 10.1093/cvr/cvy036

Figure 5.

Figure 5

Loss of Sirt3 increases plasma TF levels and activity. Sirt3−/− animals showed increased TF levels (A, n ≥ 6, Mann–Whitney test) and a higher TF activity (B, n ≥ 9, Student’s t-test) in plasma than in control animals. Liver mRNAs of locally synthesized coagulation factors V, VII, and IX were elevated in Sirt3−/− animals (C, n = 9, ∗: P = 0.0385 and 0.0402; ∗∗: P = 0.0078, factor VII and XI were analysed using the Mann–Whitney test, the other factors with Student’s t-test). However, protein plasma levels were not different (D, n = 8, Factor V analysed by Mann–Whitney test, factors VII and IX by Student’s t-test).