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. 2018 Feb 10;114(8):1178–1188. doi: 10.1093/cvr/cvy036

Figure 6.

Figure 6

Sod2 transcription is reduced in Sirt3-deficient mouse neutrophils, but not in monocytes—CD14+ leukocytes of STEMI patients show reduced SIRT3 and SOD2 transcript levels. Murine Sirt3−/− neutrophils lack Sirt3 (A) and show reduced transcription of Sod2 (B, n ≥ 8, Student’s t-test). STEMI patients demonstrate reduced mRNA levels of SIRT3 (C) and SOD2 (D) in CD14+ cells compared to healthy donors (n = 10, both Student’s t-test). CD11b+ cells from Sirt3-deficient mice show no differential transcription of Sod2 compared to WT (E and F, n = 6, Mann–Whitney test).