Table 1.
Demographic characteristics and clinical course in MSC-treated patients and in control groups of kidney transplant recipients.
| Age at Tx (years)/gender (M:F) | Donor age (years) | Cause of renal failure | HLA mismatch median (range) | Post-Tx follow-up (months) | Serum creatinine at month 6 post-Tx (mg/dL) | Serum creatinine at month 12 post-Tx (mg/dL) | Serum creatinine at last follow-up (mg/dL) | Measured GFR at month 6 post-Tx (mL/min/1.73 m2) | Measured GFR at month 12 post-Tx (mL/min/1.73 m2) | Measured GFR at month 60 post-Tx (mL/min/1.73 m2) | Measured GFR at last follow-up (mL/min/1.73 m2) | Proteinuria at month 60 post-Tx (g/24 h) | Proteinuria at last follow-up (g/24 h) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MSC-treated patients | ||||||||||||||
| MSC #1 | 22/M | 43 | Unknown | 2 | 84 | 1.83 | 1.93 | 2.27 | 49.59 | 48.41 | 47.30 | 46.61 | 0.65 | 0.91 |
| MSC #2 | 34/M | 64 | IgA nephropathy | 2 | 84 | 2.38 | 2.24 | 2.21 | 38.90 | 38.52 | 41.25 | 30.73 | 0.26 | 1.24 |
| MSC #3 | 37/M | 65 | IgA nephropathy | 2 | 72 | 1.35 | 1.23 | 0.97 | 62.79 | 59.16 | 69.14 | 76.68 | 0.07 | 0.15 |
| MSC #4 | 34/M | 61 | Medullary sponge disease | 3 | 60 | 1.37 | 1.25 | 1.49 | 51.06 | 51.04 | 48.36 | 48.36 | 0.06 | 0.06 |
| Control patients | ||||||||||||||
| Bas/low-dose RATG control group | 42 ± 15/4:2 | 44 ± 4 | IgA nephropathy (n = 3), ADPKD (n = 1), lupus nephritis (n = 1), and unknown (n = 1) | 2 (0–4) | 84 | 1.47 ± 0.40 | 1.54 ± 0.34 | 1.77 ± 0.22 | 44.83 ± 7.44 | 49.41 ± 6.79 | 48.60 ± 5.36 | 40.77 ± 5.22 | 0.42 ± 0.29 | 0.54 ± 0.31 |
| Low-dose RATG control group | 56 ± 9/5:1 | 51 ± 5 | IgA nephropathy (n = 1), ADPKD (n = 2), unknown (n = 2), and nephroangiosclerosis (n = 1) | 4 (3–5) | 60 | 1.58 ± 0.28 | 1.45 ± 0.31 | 1.94 ± 0.40 | 44.71 ± 5.09 | 46.01 ± 6.47 | 42.18 ± 5.44 | 42.18 ± 5.44 | 0.52 ± 0.39 | 0.52 ± 0.39 |
Data from control groups are mean ± SEM.
ADPKD, autosomal dominant polycystic kidney disease; Bas, basiliximab; GFR, glomerular filtration rate; IgA, immunoglobulin A; RATG, rabbit anti-thymocyte globulin; Tx, transplantation; HLA, human leukocyte antigen; MSC, mesenchymal stromal cell.