FIGURE 7:

Comparison of PMN crawling speed on various ligands. Crawling speed of resting (A, B) or fMLF-activated (C, D) PMNs pretreated with isotype control (black bars) or LFA-1 (red bars)/Mac-1 (blue bars) blocking mAbs on various ligands at 1 dyn/cm² (A, C) or 10 dyn/cm² (B, D). Data are presented as the mean ± SEM from a total of 18–139 cells of five to nine independent experiments and analyzed with two-way ANOVA (followed by a Holm–Sidak test). Significant differences were indicated by *, p < 0.05; **, p < 0.01; ***, p < 0.001 among various ligands, by ^#, p < 0.05; ^##, p < 0.01; ^###, p < 0.001 between each blocking group and isotype control, or by ^$, p < 0.05; ^$$, p < 0.01; ^$$$, p < 0.001 between LFA-1– and Mac-1–blocking groups.