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. 2018 Feb 15;29(4):466–478. doi: 10.1091/mbc.E17-07-0451

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© 2018 Howard-Till and Loidl. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 9: — Condensin depletion causes chromosome clustering in somatic nuclei. (A) Representative images from FISH of a 79-kb chromosome in the somatic nucleus show examples of evenly distributed, unevenly distributed, or clustered chromosomes. Quantitation of chromosome clustering in smc2i, cph3i, and cpdt1i cells shows the various effects of depleting different condensin subunits. Temporal analysis after induction of RNAi in smc2i cells shows a gradual increase in chromosome clustering. RNAi was induced in starved cells, which were then refed to induce cell division and fixed at the indicated time points. (B) FISH of two different chromosomes shows nonoverlapping clusters, with various degrees of clustering for different probes. Scale bar equals 5 μm in A and B.