Table 4.

Association between baseline diabetes medication category and 2-year mortality

	Adjusted mortality rate* (95% CI)	Risk difference (95% CI)	P values	HR† (95% CI)	P values
Full cohort
Non-sulfonylurea	6.5% (5.1 to 7.9)	Ref	Ref	Ref	Ref
Sulfonylurea	9.7% (7.7 to 11.8)	3.2 (0.7 to 5.7)	0.01	1.38 (1.00 to 1.93)	0.05
No medications	5.9% (5.0 to 6.9)	−0.6 (−2.2 to 1.1)	0.5	1.02 (0.77 to 1.35)	0.9
Excluding participants with CKD or on dialysis
Non-sulfonylurea	5.5% (4.4 to 6.7)	Ref	Ref	Ref	Ref
Sulfonylurea	8.4% (5.9 to 10.9)	2.9 (0.1 to 5.6)	0.04	1.52 (1.04 to 2.21)	0.03
No medications	4.7% (3.7 to 5.6)	−0.9 (−2.4 to 0.6)	0.24	1.03 (0.76 to 1.38)	0.87

*All-cause mortality rate in each medication category in the inverse probability of treatment-weighted population.

†HR for 2-year mortality in individuals taking sulfonylureas or no medications compared with those taking non-sulfonylurea medication in inverse probability of treatment-weighted Cox proportional hazards models additionally adjusted for chronic kidney disease and dialysis.

CKD, chronic kidney disease ref, reference.