Table 1.
Results of enrichment analysis of DEGs.
| Terms | Count | p value | Genes |
|---|---|---|---|
| Up-regulated genes enriching BP | |||
| GO:0006412∼translation | 33 | 1.23E-16 | MRPS16, PABPC4, MRPS10, RPS15A, RPL13AP20, DTD1, RPL21P28, RPS3, MRPL11, EIF3G, RPL9, RPLP0, EIF1AY, RPL26L1, MRPL37, EIF3I, EIF3M, RPS27A, MRPL35, RPL36AL, EEF1A1, RPSAP19, RPL27, RPS9, MRPS21, MRPS7, ETF1, RPS5, RPS19, MRPL27, RPS14, EIF2S1, MRPL47 |
| GO:0006414∼translational elongation | 14 | 6.47E-9 | EEF1A1, RPSAP19, RPS9, RPL27, RPS15A, RPS5, RPS3, RPL21P28, RPS19, RPLP0, RPL9, RPS14, RPL26L1, RPS27A |
| GO:0006119∼oxidative phosphorylation | 12 | 4.03E-7 | NDUFB3, NDUFB5, UQCR11, NDUFB7, NDUFAB1, ATP5F1, NDUFS2, ATP5H, ATP5G3, NDUFS1, ATP6V1F, UQCRHL |
| GO:0031397∼negative regulation of protein ubiquitination | 10 | 2.38E-6 | PSMB7, GTPBP4, PSMB6, PSMC5, PSMB1, PSMA5, PSME3, PSMB8, RPS27A, PSMB9 |
| GO:0031400∼negative regulation of protein modification process | 12 | 2.84E-6 | PSMB7, GTPBP4, PSMB6, PSMC5, PSMB1, PSMA5, NLRP12, PEBP1, PSME3, PSMB8, RPS27A, PSMB9 |
| Up-regulated genes enriching CC | |||
| GO:0005840∼ribosome | 27 | 3.98E-16 | MRPS16, MRPS10, RPS15A, RPL13AP20, RPL21P28, RPS3, MRPL11, RPLP0, RPL9, RPL26L1, MRPL54, MRPL37, RPS27A, MRPL35, RPL36AL, RPSAP19, MRPS23, RPS9, RPL27, MRPS21, MRPS7, RPS5, RPS19, MRPL27, RPS14, MRPL47, MRPL46 |
| GO:0030529∼ribonucleoprotein complex | 38 | 5.29E-15 | MRPS16, STRAP, PABPC4, CWC15, SNRPD1, MRPS10, RPS15A, RPL13AP20, SF3B4, RPL21P28, RPS3, MRPL11, RPL9, RPLP0, RPL26L1, MRPL54, PPIL3, MRPL37, LSM3, RPS27A, MRPL35, RPL36AL, BCAS2, TXNL4B, RPSAP19, MRPS23, RPL27, RPS9, MRPS21, MRPS7, RPS5, RPS19, MRPL27, RPS14, EIF2S1, MRPL47, POP4, MRPL46 |
| GO:0044429∼mitochondrial part | 39 | 9.30E-14 | NDUFB3, MRPS16, NDUFB5, NDUFB7, COX7B, NDUFAB1, TIMM10, ECHS1, TIMM50, TIMM13, SFXN2, COX5A, ATP5G3, DTD1, MRPL11, ACSL1, UQCR11, PARL, COX6B1, MRPL37, ATP5H, NDUFS2, NDUFS1, MRPL35, ACAA2, SLC25A5, SLC25A6, ATP5F1, COX4I1, MRPS21, TIMM8B, UQCRHL, PPIF, MRPL27, PEBP1, MRPL47, TOMM22, PMPCA, SURF1 |
| GO:0005743∼mitochondrial inner membrane | 28 | 2.97E-13 | NDUFB3, NDUFB5, NDUFB7, COX7B, TIMM10, NDUFAB1, TIMM50, TIMM13, SFXN2, COX5A, ATP5G3, UQCR11, PARL, COX6B1, NDUFS2, ATP5H, NDUFS1, ACAA2, SLC25A5, SLC25A6, ATP5F1, COX4I1, TIMM8B, UQCRHL, PPIF, TOMM22, SURF1, PMPCA |
| GO:0005739∼mitochondrion | 52 | 5.69E-13 | GM2A, NDUFAB1, TIMM50, COX5A, C14ORF2, MTHFD2, UQCR11, PARL, MRPL37, ATP5H, NDUFS2, NDUFS1, MRPL35, ACAA2, SLC25A5, SLC25A6, COX4I1, MRPS7, TIMM8B, TMEM186, PEBP1, MRPL47, TOMM22, PMPCA, SURF1, MRPL46, NDUFB3, MRPS16, NDUFB5, NAPG, NDUFB7, COX7B, TIMM10, MRPS10, ECHS1, CHCHD2, TIMM13, SFXN2, ATP5G3, DTD1, MRPL11, ACSL1, MRPL54, COX6B1, MRPS23, ATP5F1, MRPS21, UQCRHL, PPIF, MRPL27, ALKBH3, VPS25 |
| Up-regulated genes enriching MF | |||
| GO:0003735∼structural constituent of ribosome | 24 | 5.92E-16 | RPSAP19, MRPS16, MRPS10, RPS15A, RPS9, RPL27, MRPS21, RPL13AP20, MRPS7, RPS5, RPS3, RPL21P28, MRPL11, RPS19, MRPL27, RPS14, RPL9, RPLP0, RPL26L1, MRPL37, MRPL47, RPS27A, MRPL35, RPL36AL |
| GO:0015078∼hydrogenion transmembrane transporter activity | 11 | 9.80E-7 | UQCR11, COX7B, COX6B1, ATP5F1, COX4I1, COX5A, SURF1, ATP5H, ATP5G3, ATP6V1F, UQCRHL |
| GO:0005198∼structural molecule activity | 28 | 1.02E-6 | MRPS16, MRPS10, RPS15A, RPL13AP20, TPM4, RPL21P28, RPS3, MRPL11, RPLP0, RPL9, RPL26L1, TUBB6, MRPL37, RPS27A, MRPL35, RPL36AL, RPSAP19, RPS9, RPL27, MRPS21, MRPS7, EMILIN2, RPS5, RPS19, MRPL27, RPS14, MRPL47, LAMC1 |
| GO:0003723∼RNA binding | 29 | 3.53E-6 | CNBP, PABPC4, CWC15, SNRPD1, RPS15A, TIMM50, SF3B4, RPL21P28, RPS3, MRPL11, EIF3G, RPLP0, RPL9, NUDT21, EIF1AY, LSM3, NXF3, RPS9, MRPS7, ETF1, CRYZ, RPS5, RPS19, ABT1, RPS14, EIF2S1, PSPC1, CIRBP, POP4 |
| GO:0015077∼monovalent inorganic cation transmembrane transporter activity | 11 | 3.73E-6 | UQCR11, COX7B, COX6B1, ATP5F1, COX4I1, COX5A, SURF1, ATP5H, ATP5G3, ATP6V1F, UQCRHL |
| Up-regulated genes enriching pathway | |||
| hsa05012:Parkinson's disease | 17 | 1.96E-9 | NDUFB3, NDUFB5, NDUFB7, SLC25A5, SLC25A6, COX7B, ATP5F1, NDUFAB1, COX4I1, COX5A, ATP5G3, UQCRHL, UQCR11, COX6B1, NDUFS2, ATP5H, NDUFS1 |
| hsa00190:Oxidative phosphorylation | 16 | 2.02E-8 | NDUFB3, NDUFB5, NDUFB7, COX7B, ATP5F1, NDUFAB1, COX4I1, COX5A, ATP5G3, UQCRHL, ATP6V1F, UQCR11, COX6B1, NDUFS2, ATP5H, NDUFS1 |
| hsa05016:Huntington's disease | 18 | 4.42E-8 | NDUFB3, NDUFB5, NDUFB7, SLC25A5, SLC25A6, AP2S1, COX7B, ATP5F1, NDUFAB1, COX4I1, COX5A, ATP5G3, UQCRHL, UQCR11, COX6B1, NDUFS2, ATP5H, NDUFS1 |
| hsa03010:Ribosome | 13 | 8.01E-8 | RPSAP19, RPS9, RPL27, RPS15A, RPS5, RPS3, RPL21P28, RPS19, RPLP0, RPL9, RPL26L1, RPS27A, RPL36AL |
| hsa05010:Alzheimer's disease | 15 | 2.47E-6 | NDUFB3, NDUFB5, NDUFB7, COX7B, ATP5F1, NDUFAB1, COX4I1, COX5A, ATP5G3, UQCRHL, UQCR11, COX6B1, NDUFS2, ATP5H, NDUFS1 |
| Down-regulated genes | |||
| GO:0004672∼protein kinase activity | 6 | 0.037 | TYK2, FASTKD1, ITGAE, PDK4, MAP3K8, MAP3K12 |
DEGs: differentially expressed genes; BP: biological process; CC: cell component; MF: molecular function; GO: gene ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes