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Schematic diagram of ROS/Akt/p38 MAPK signaling pathway in COM crystals-induced tight junction disruption. COM crystals stimulate the generation of ROS, which activate the phosphorylation of Akt. Akt in turn activates ASK1 by phosphorylating ASK1 on Thr838 that further triggers p38 MAPK activation, leading to the disruption of tight junction in MDCK cells.
