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. 2018 Jun 19;6:e5092. doi: 10.7717/peerj.5092

Figure 1. The phosphoinositide 3-kinase pathway and inhibitors of the pathway in cancer.

Figure 1

Tumor promoters and suppressors are labeled in orange and green, respectively. Study sites: RTK, receptor tyrosine kinase; GPCR, G-protein-coupled receptor; PI3K, phosphatidylinositol 3-kinase; PIP2, phosphatidylinositol 4,5-bisphosphate; PIP3, phosphatidylinositol 3,4,5-trisphosphate; PDK1, phosphoinositide dependent kinase-1; PTEN, phosphatase and tensin homolog; INPP4B: inositol polyphosphate 4-phosphatase type II; mTORC, mammalian target of rapamycin complex; SK6, S6 kinase; 4EBP1, 4E-binding protein 1.