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. 2016 Nov 21;39(1):258–264. doi: 10.1080/0886022X.2016.1256322

Figure 1.

Figure 1.

Morphine and opioid receptor agonists stimulate 786-O proliferation. (A) after 48 h of incubation, 50μM each of morphine, MOR, DOR, and KOR agonists (DAMGO,DPDPE {[D-Pen (2, 5)]-Enkephalin} and U-50488H {trans-()-3,4-Dichloro-N-methyl-N-(2-[1-Pyrrolidinyl] Cyclohexyl) -Benzeneacetamide}, respectively) stimulated 786-O proliferation, under serum-free (▪) as well asserum-replete (□)conditions. ※, P < .05; #, P < .01. (B) Morphine cannot stimulate CHO cell proliferation. (C,D) Morphine concentration-dependent stimulation of 786-O,RLC-310 proliferation after 48 h of incubation. ※, P < .05; #, P < .01 compared to without morphine. Each experiment was repeated three times in triplicates, and each value indicates mean; bars ± SD.