Table 1.
Baseline continuous variables of the study groups.
| Cinacalcet group, N = 23 | Control group, N = 101 | p value | Cinacalcet group with AE, N = 12 | Cinacalcet group without AE, N = 11 | p value | |
|---|---|---|---|---|---|---|
| Age (years) | 62 ± 10 | 68 ± 11 | .017 | 64 ± 8 | 60 ± 10 | .291 |
| Time on HD (years) | 13.6 ± 4.9 | 5.4 ± 5.2 | <.001 | 13.6 ± 4.4 | 13.5 ± 5.1 | .986 |
| Dry weight (kg) | 57.3 ± 9.8 | 54.8 ± 12.9 | .380 | 53.7 ± 7.0 | 61.2 ± 10.4 | .060 |
| Corrected Ca (mg/dL)a | 9.3 ± 0.7 | 9.0 ± 0.7 | .036 | 9.2 ± 0.6 | 9.3 ± 0.7 | .673 |
| Phosphorus (mg/dL) | 5.6 ± 1.4 | 5.0 ± 1.2 | .048 | 5.9 ± 1.5 | 5.2 ± 1.0 | .230 |
| ALP (IU/L) | 228 ± 86 | 265 ± 127 | .187 | 275 ± 91 | 176 ± 22 | .003 |
| Whole PTH (pg/mL) | 120 ± 72 | 87 ± 51 | .047 | 113 ± 23 | 127 ± 61 | .646 |
| Hemoglobin (g/dL) | 11.3 ± 1.0 | 11.1 ± 0.9 | .341 | 11.5 ± 0.7 | 11.1 ± 1.2 | .419 |
| TSAT (%) | 19.8 ± 8.8 | 25.9 ± 11.4 | .019 | 19.7 ± 7.4 | 20.0 ± 9.8 | .925 |
| Ferritin (ng/mL) | 101 ± 162 | 162 ± 268 | .293 | 142 ± 204 | 55 ± 54 | .203 |
| Total protein (g/dL) | 6.5 ± 0.4 | 6.4 ± 0.5 | .864 | 6.5 ± 0.5 | 6.4 ± 0.4 | .379 |
| Albumin (g/dL) | 3.9 ± 0.2 | 3.8 ± 0.3 | .011 | 4.0 ± 0.3 | 3.9 ± 0.2 | .964 |
| BUN (mg/dL) | 60.1 ± 11.6 | 55.2 ± 13.9 | .122 | 60.2 ± 13.0 | 59.9 ± 9.2 | .937 |
| Creatinine (mg/dL) | 12.0 ± 2.8 | 9.5 ± 2.4 | <.001 | 11.3 ± 2.6 | 12.9 ± 2.7 | .177 |
| Kt/Vb | 1.6 ± 0.3 | 1.5 ± 0.3 | .039 | 1.67 ± 0.16 | 1.59 ± 0.35 | .541 |
| Potassium (mEq/L) | 5.2 ± 0.7 | 4.8 ± 0.8 | .044 | 5.2 ± 0.7 | 5.1 ± 0.7 | .664 |
| LDL-C (mg/dL) | 96 ± 26 | 81 ± 26 | .013 | 98.1 ± 21.0 | 93.7 ± 29.6 | .700 |
| β2-MG (mg/L) | 27.9 ± 3.7 | 25.9 ± 6.2 | .044 | 28.2 ± 4.0 | 27.6 ± 3.2 | .745 |
Values are mean ± SD; AE: adverse events.
a
Corrected Ca = serum calcium + (4-serum albumin); ALP: alkaline phosphatase; PTH: parathyroid hormone; TSAT: transferrin saturation; BUN: blood urea nitrogen; LDL-C: low-density lipoprotein cholesterol; β2-MG: β2-microglobulin.
b
Kt/V calculation is Daugirdas’s formula (1996): spKt/V = −ln(R − 0.008 × t) + (4 − 3.5 × R) 0.55 × UF/V: in which R is predialysis urea/postdialysis urea, t is dialysis time in hours.