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. 2018 Jun 21;6(12):e13738. doi: 10.14814/phy2.13738

Figure 2.

Figure 2

Voluntary running attenuates NLRP3 inflammasome activation in HFD feeding mice heart. Representative western blot images show the inhibitory effect of voluntary running exercise on NLRP3 inflammasome components and IL‐1β expression in mouse hearts (A). Summarized data show the effect of HFD or voluntary running on the relative proteins expression levels of NLRP3 (B), ASC (C), inactive procaspase‐1 (D), active caspase‐1 p20 (E), the p20/procaspase‐1 ratio (F), and matured IL‐1β (G) in mouse hearts. Values are means ± SEM. n = 6–9/group. *P < 0.05 versus LF‐SED. NLRP3, nucleotide‐binding oligomerization domain‐like receptor family pyrin domain‐containing 3; HFD, high‐fat diet; IL, interleukin; ASC, apoptosis‐associated speck‐like protein containing; LF‐SED, low‐fat diet with sedentary.