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. 2018 Jun 21;6(12):e13748. doi: 10.14814/phy2.13748

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Evaluation of coronary flow after administration of Paxilline (n = 5) or Iberiotoxin (n = 4). (A) Absolute reduction in mean coronary velocity. (B) Absolute reduction in mean coronary gradient. (C) Fold change in mean coronary velocity. (D) Fold change in mean coronary gradient. Velocity through the left main coronary artery was found to be decreased 1 min after administration of high‐dose Paxilline. This reduction in flow normalized at 15 min. Mean coronary gradient in this particular group was also found to be decreased.