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. 2018 Apr 5;40(1):280–288. doi: 10.1080/0886022X.2018.1456462

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Blockage of STAT5 activation attenuates IL-2-induced Tregs expansion and FoxP3 mRNA expression in PBMCs from 10 CKD patients. (a) A typical example dot plot of the gating strategy CD4⁺CD25⁺ FoxP3⁺ and CD4⁺CD25^hi for Tregs by flow cytometry-based cell characterizing is given. (b) Block of activation of STAT5 by pimozide-attenuated IL-2-induced CD4⁺CD25⁺ FoxP3⁺ Tregs expansion is depicted in the graph (n = 9). The data are expressed as the mean ± SEM, with nine patients per group. (c) Block of activation of STAT5 by pimozide-attenuated IL-2-induced CD4⁺CD25^hi Tregs expansion is depicted in the graph (n = 7). The data are expressed as the mean ± SEM. (d) Block of activation of STAT5 by pimozide-attenuated IL-2-induced expression of FoxP3 mRNA is depicted in the graph. The data are expressed as the mean ± SEM. p Values are depicted in the graph. *p < .05, **p < .01 for comparisons between the IL-2 treated group and the non-IL-2 treated group using one-way ANOVA analysis.