Table 2.

Association of baseline A1C and wound healing in multivariable Cox models

		Unadjusted (n = 584)			Model 1* (n = 583)			Model 2† (n = 528)
Baseline A1C	N	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
6.5–8.0%	162	1.00	Ref	—	1.00	Ref	—	1.00	Ref	—
<6.5%	149	1.00	0.69–1.47	0.96	0.99	0.69–1.43	0.96	0.97	0.65–1.44	0.89
>8.0%	298	1.18	0.89–1.58	0.26	1.13	0.83–1.54	0.44	0.97	0.70–1.36	0.87

N, number of wounds.

P values <0.05 are statistically significant.

*Model 1 adjusted for age, sex, and race; one observation was dropped due to missing race.

†Model 2 adjusted for age, sex, race, smoking status, neuropathy (LOPS), prior amputation, quartiles of insulin dose (units/kg/day), metformin use, sulfonylurea use, wound intervention (surgery vs. wound care only), eGFR category, kidney transplant, A1C target (<7.5% vs. ≥7.5%), and antibiotic use; 56 observations were dropped from model 2: 54 missing eGFR, 1 missing race, and 1 missing insulin dose.