Table 3.

Association of A1C change from baseline and long-term (≥90 day) wound healing among wounds with baseline A1C <7.5%

		Unadjusted (n = 129)			Model 1 (n = 129)			Model 2 (n = 118)			Model 3 (n = 117)
	N	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
ΔNadir A1C
Tertile 1 (−1.7 to −0.3)	47	0.67	0.41–1.09	0.11	0.64	0.36–1.14	0.13	0.85	0.48–1.50	0.58	0.85	0.48–1.51	0.29
Tertile 2 (−0.29 to 0.0)	54	1.00	Ref	—	1.00	Ref	—	1.00	Ref	—	1.00	Ref	—
Tertile 3 (0.09–2.4)	28	1.29	0.77–2.17	0.34	1.30	0.76–2.22	0.34	1.90	1.03–3.53	0.04	2.07	1.08–4.00	0.03
ΔMean A1C
Tertile 1 (−1.4 to 0.0)	69	1.02	0.54–1.95	0.07	0.96	0.39–2.38	0.93	0.78	0.30–2.02	0.61	0.85	0.27–2.72	0.79
Tertile 2 (0.02–0.3)	17	1.00	Ref	—	1.00	Ref	—	1.00	Ref	—	1.00	Ref	—
Tertile 3 (0.35–4.25)	43	1.20	0.62–2.35	0.55	1.19	0.45–3.10	0.73	0.97	0.33–2.84	0.96	1.06	0.32–3.56	0.93

N, number of wounds; Δ, change (from baseline).

Bold values indicate statistical significance (P < 0.05).

Model 1: adjusted for WIfI classification system (stage 1–4) and wound intervention (wound care vs. surgery). Model 2: adjusted for WIfI, wound intervention, age, smoking status, antibiotic use, eGFR stages, history of kidney transplant, and history of amputation; 11 observations were dropped due to missing eGFR data. Model 3: adjusted for WIfI, wound intervention, age, smoking status, antibiotic use, eGFR stages, history of kidney transplant, history of amputation, and total insulin dose (units/kg) assessed in tertiles (tertile 1: 0.00; tertile 2: 0.11–0.26; tertile 3: 0.27–3.28); 12 observations were dropped (11 missing eGFR data and 1 missing insulin dose).