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. 2018 May 3;67(7):1297–1309. doi: 10.2337/db17-1509

Figure 3.

Figure 3

mRNA levels of regulators of lipid metabolism are unaffected by the HFD in Pik3r1 R649W mice. Serum levels of leptin (A) and adiponectin (B) in WT and KI animals fed the CD or HFD (n = 4–8 animals per group). Results are shown as mean ± SEM. #P < 0.0005, one-way ANOVA. mRNA levels of genes involved in lipid metabolism (C), adipocyte development (D), and inflammation (E) in the inguinal fat pad (top panels) and epididymal fat pad (bottom panels) after 8 weeks of the CD or HFD. mRNA results are mean ± SEM (n = 5–6 animals per group). *P < 0.05, **P < 0.01 by t tests, compared with controls.