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. 2018 May 3;67(7):1297–1309. doi: 10.2337/db17-1509

Figure 6.

Figure 6

Pik3r1 R649W mice show resistance to genetically induced obesity but worsened the diabetic phenotype. A: Body weight of WT and Pik3r1 R649W KI mice measured over 6 weeks in control mice (circles) and ob/ob mutation (squares). Results shown as mean ± SEM (n = 4–12 mice per group). #P < 0.0005, one-way ANOVA. Blood glucose (B) and serum insulin (C) levels in the fed state and after 3 h of fasting at 8 weeks of age. Results are shown as mean ± SEM of 4–12 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001 #P < 0.0005, t tests. iWAT (D), eWAT (E), and BAT (F) weight at 8 weeks of age (mean ± SEM of 4–12 animals per group). **P < 0.01, ***P < 0.001, #P < 0.0005 compared with controls, one-way ANOVA. G: Formalin-fixed WAT sections from representative inguinal and epididymal depots and average adipocyte area (n = 4). Results are shown as mean ± SEM. #P < 0.0005, one-way ANOVA.