Figure 2.
A: Manhattan plot of P values from the meta-analysis of allelic effects on early DKD in subjects with T2D of European descent. The red line represents genome-wide significance (P < 5 × 10−8) and the blue line suggestive significance (P < 1 × 10−6). The peak represented by rs9942471 (P = 4.5 × 10−8) near GABRR1 is highlighted in orange. B: A forest plot of allelic OR and imputation information scores (RSQ) from individual studies that contributed to the discovery and replication analyses of rs9942471 in microalbuminuria phenotype; rs9942471 genotypes were not available in Steno. C: A LocusZoom plot of the signal near GABRR1 led by rs9942471 that was associated with microalbuminuria in European subjects with T2D.