Table 2.
Five loci were associated (P ≤ 5 × 10−8) with CKD, microalbuminuria, and eGFR phenotypes in T2D or T1D+T2D subjects
| CHR:BP | Phenotype | SNP (locus) | Discovery |
Replication |
Joint analysis |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| EA/NEA (Info), EAF | OR/β (95% CI) | P | Ancestry | OR/β (95% CI) | P | OR/β (95% CI) | P | N | |||
| 20: 9351150 |
T2D CKD |
rs2206136 (PLCB4) |
A/T (0.98), 0.42 |
OR 1.20 (1.08, 1.34) |
2.1 × 10−8 |
European |
OR 1.02 (0.91, 1.15) |
0.69 |
OR 1.13 (1.05, 1.21) |
9.0 × 10−5 |
11,900 |
| Asian and European |
OR 1.03 (0.94, 1.13) |
0.68 |
OR 1.12 (1.05, 1.19) |
2.1 × 10−4 |
13,813 |
||||||
| 6: 89948232 |
T2D microalbu-minuria |
rs9942471 (GABRR1) |
A/C (0.99), 0.64 |
OR 1.24 (1.15, 1.34) |
2.1 × 10−7 |
European |
OR 1.32 (0.99, 1.75) |
0.06 |
OR 1.25 (1.16, 1.34) |
4.5 × 10−8 |
4,801 |
| Asian and European |
OR 1.11 (0.99, 1.23) |
0.12 |
OR 1.15 (1.08, 1.23) |
1.2 × 10−5 |
5,559 |
||||||
| 16: 20400839 |
T2D eGFR |
rs11864909 (UMOD) |
T/C (1.00), 0.28 |
β 2.42 (1.28, 3.56) |
2.7 × 10−5 |
European |
β 2.22 (1.16, 3.28) |
4.1 × 10−5 |
β 2.31 (1.54, 3.09) |
4.6 × 10−9 |
12,343 |
| Asian and European |
β 2.30 (1.48, 3.12) |
3.6 × 10−8 |
β 2.34 (1.68, 3.00) |
4.4 × 10−12 |
19,747 |
||||||
| 2: 170646916 |
T1D+T2D eGFR |
rs1974990* (SSB) |
G/T (0.98), 0.08 |
β 4.07 (2.61, 5.52) |
4.8 × 10−8 |
European |
No replication available |
β 4.07 (2.61, 5.52) |
4.8 × 10−8 |
13,158 |
|
| Asian and European |
β 0.04 (−2.69, 2.76) |
0.98 |
β 3.17 (1.88, 4.45) |
1.4 × 10−6 |
14,828 |
||||||
| 7: 151415041 |
T1D+T2D eGFR |
rs10224002 (PRKAG2) |
A/G (0.92), 0.74 |
β 1.75 (0.85, 2.66) |
1.5 × 10−4 |
European |
β 2.15 (0.93, 3.37) |
5.8 × 10−4 |
β 1.89 (1.17, 2.62) |
3.4 × 10−7 |
20,495 |
| Asian and European |
β 2.42 (1.28, 3.56) |
3.2 × 10−5 |
β 2.01 (1.30, 2.72) |
2.7 × 10−8 |
22,165 |
||||||
| 16: 20400839 | T1D+T2D eGFR | rs11864909 (UMOD) | T/C (0.99), 0.29 | β 1.90 (1.05, 2.74) | 1.1 × 10−5 | European |
β 2.22 (1.16, 3.28) |
4.1 × 10−5 |
β 2.02 (1.36, 2.69) |
2.1 × 10−9 |
16,304 |
| Asian and European | β 2.30 (1.48, 3.12) | 3.6 × 10−8 | β 2.11 (1.52, 2.70) | 2.3 × 10−12 | 23,708 | ||||||
BP, base pair; CHR, chromosome; EA, effect allele; EAF, effect allele frequency; NEA, non-effect allele.
*rs1974490 was only available in the 1000G reference panel and was not imputed in the European studies used in the replications.