Table 2.
Lead SNPs associated with HbA1c response in common variant analysis in all races combined (P < 5 × 10−6)
| SNP | Chromosome | Position | Gene | Type | MAF | β | P value |
|---|---|---|---|---|---|---|---|
| rs7371352 |
2 |
205916609 |
NA |
IMPU |
0.461 |
0.166 |
1.29E-06 |
| rs12694529 |
2 |
220685415 |
NA |
META |
0.131 |
0.232 |
1.06E-06 |
| rs2371651 |
3 |
64899735 |
ADAMTS9-AS2 |
IMPU |
0.346 |
0.171 |
4.89E-06 |
| rs36050186 |
3 |
73884807 |
LOC105377165 |
IMPU |
0.061 |
0.315 |
4.46E-06 |
| rs28535480 |
3 |
144238665 |
LOC105374140 |
IMPU |
0.447 |
0.184 |
4.12E-07 |
| rs7669299 |
4 |
77525989 |
CXCL13 |
GENO |
0.106 |
−0.348 |
5.88E-07 |
| rs79827403 |
4 |
140248372 |
NA |
IMPU |
0.046 |
−0.386 |
2.19E-06 |
| rs6884548 |
5 |
104706194 |
LOC105379109 |
IMPU |
0.038 |
0.439 |
2.64E-06 |
| rs56061109 |
5 |
113100738 |
MCC |
IMPU |
0.048 |
0.394 |
6.00E-07 |
| rs6903843 |
6 |
3125135 |
BPHL |
IMPU |
0.031 |
0.587 |
3.36E-06 |
| rs79573377 |
6 |
91226278 |
NA |
IMPU |
0.033 |
0.437 |
3.19E-06 |
| rs59506474 |
6 |
136927217 |
NA |
IMPU |
0.066 |
−0.355 |
1.57E-06 |
| rs2578120 |
10 |
78453110 |
NA |
IMPU |
0.358 |
−0.160 |
2.53E-06 |
| rs7307035 |
12 |
53778761 |
LOC107984525 |
META |
0.033 |
−0.440 |
1.77E-06 |
| rs12300320 |
12 |
93077216 |
LOC643339 |
IMPU |
0.053 |
−0.386 |
3.01E-06 |
| rs12827634 |
12 |
95026750 |
NR2C1 |
IMPU |
0.362 |
0.154 |
3.18E-06 |
| rs57081354 |
13 |
35202456 |
NBEA |
GENO |
0.077 |
0.326 |
4.02E-08 |
| rs4144603 |
14 |
96729576 |
NA |
META |
0.405 |
0.159 |
1.36E-06 |
| rs7173199 |
15 |
29424654 |
FAM189A1 |
IMPU |
0.046 |
0.419 |
1.77E-06 |
| rs182384419 |
15 |
79438983 |
KIAA1024 |
IMPU |
0.043 |
0.394 |
2.66E-06 |
| rs74007109 |
16 |
6852072 |
RBFOX1 |
IMPU |
0.040 |
0.407 |
2.92E-06 |
| rs2529698 |
17 |
12350355 |
NA |
META |
0.061 |
0.331 |
9.24E-07 |
| rs254271 |
19 |
54630757 |
PRPF31 |
IMPU |
0.330 |
0.163 |
3.79E-06 |
| rs6139020 | 20 | 3156571 | UBOX5 | IMPU | 0.102 | 0.257 | 3.08E-06 |