Table 1.
Comparisons of genotypes and alleles frequencies of TNF-α −308 G > A and -238G > A polymorphisms in melanoma cases and controls.
| Polymorphism | Cases (n = 110) | Control (n = 120) | OR (95% CI) | p-value |
|---|---|---|---|---|
| TNF-α-308 G > A | ||||
| Genotypes | ||||
| GG | 79 (71.8) | 85 (70.8) | 1.00 | |
| AG | 30 (27.2) | 33 (27.5) | 0.989 (0.553–1.766) | 0.969 |
| AA | 1 (0.9) | 2 (1.6) | 0.541 (0.048–6.054) | 0.618 |
| Allele | ||||
| G | 203 (92.3) | 194 (80.8) | 1.00 | |
| A | 17 (7.7) | 46 (19.2) | 0.353 (0.196–0.637) | 0.001 |
| TNF-α -238G > A | ||||
| Genotypes | ||||
| GG | 91 (82.7) | 105 (87.5) | 1.00 | |
| AG | 19 (17.3) | 14 (11.7) | 1.581 (0.750–3.330) | 0.228 |
| AA | 0 (0.0) | 1 (0.8) | 0.360 (0.015–8.942) | 0.533 |
| Allele | ||||
| G | 201 (91.4) | 224 (93.3) | 1.00 | |
| A | 19 (8.6) | 16 (6.7) | 1.323 (0.663–2.643) | 0.427 |
OR: Odds Ratio; CI: Confidence Interval.