Table 2.
Characteristics of the individual studies included in the meta-analysis.
| First Author | Country (Ethnicity) |
SOC | Genotyping Method |
Case/Control | Cases |
Control |
MAFs | HWE | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotypes |
Alleles |
Genotypes |
Alleles |
|||||||||||||
| TNF-α −308 G > A | GG | AG | AA | G | A | GG | AG | AA | G | A | ||||||
| Moos 200023 | Germany(Caucasian) | HB | RFLP-PCR | 55/240 | 36 | 18 | 1 | 90 | 20 | 166 | 74 | 0 | 406 | 74 | 0.154 | 0.004 |
| Sezgin 200824 | Turkey(Caucasian) | HB | NS | 151/84 | 121 | 26 | 4 | 268 | 34 | 72 | 12 | 0 | 156 | 12 | 0.071 | 0.480 |
| Han 201225 | Korea(Asian) | PB | RFLP-PCR | 301/291 | 79 | 188 | 34 | 346 | 256 | 258 | 33 | 0 | 549 | 33 | 0.056 | 0.305 |
| Ji 201326 | China(Asian) | PB | TaqMan | 200/305 | 143 | 50 | 7 | 336 | 64 | 253 | 50 | 2 | 556 | 54 | 0.088 | 0.781 |
| Munoz-Valle 201427 | Mexico(Mixed) | PB | RFLP-PCR | 50/100 | 44 | 6 | 0 | 94 | 6 | 93 | 7 | 0 | 193 | 7 | 0.035 | 0.716 |
| Vnukov 201628 | Russia(Caucasian) | NS | NS | 117/94 | 84 | 31 | 2 | 199 | 35 | 65 | 26 | 3 | 156 | 32 | 0.170 | 0.839 |
| Abdel Galil 201729 | Egypt(African) | NS | TaqMan | 210/210 | 180 | 25 | 2 | 386 | 34 | 115 | 82 | 13 | 314 | 106 | 0.257 | 0.748 |
| Sobhan 2018 | Iran(Asian) | PB | RFLP-PCR | 110/120 | 79 | 30 | 1 | 203 | 17 | 85 | 33 | 2 | 194 | 46 | 0.191 | 0.909 |
| TNF-α -238 G > A | GG | GA | AA | G | A | GG | GA | AA | G | A | ||||||
| Ji 201326 | China(Asian) | PB | TaqMan | 200/305 | 186 | 14 | 0 | 386 | 14 | 282 | 23 | 0 | 587 | 23 | 0.037 | 0.493 |
| Munoz-Valle 201427 | Mexico(Mixed) | PB | RFLP-PCR | 50/100 | 47 | 3 | 0 | 97 | 3 | 89 | 11 | 0 | 189 | 11 | 0.055 | 0.560 |
| Sobhan 2018 | Iran(Asian) | PB | RFLP-PCR | 110/120 | 91 | 19 | 0 | 201 | 19 | 105 | 14 | 1 | 224 | 16 | 0.066 | 0.493 |
SOC: Source of Control; HB: Hospital Based; PB: Population Based; NS: Not Stated; PCR-RFLP: Polymerase Chain Reaction-Restriction Fragment Length Polymorphism; MAF: Minor Allele Frequency; HWE: Hardy–Weinberg Equilibrium.