Table 3.

The meta-analysis of TNF-α -308 G > A and -238 G > A polymorphisms with knee OA risk.

Subgroup	Genetic Model	Type of Model	Heterogeneity		Odds Ratio				Publication Bias
			I2 (%)	PH	OR	95% CI	Ztest	POR	PBeggs	PEggers
TNF-α -308 G > A
Overall	A vs. G	Random	96.70	≤0.001	1.268	0.467–3.444	0.466	0.641	0.901	0.602
	AA vs. GG	Random	82.39	≤0.001	2.302	0.329–16.091	0.840	0.401	0.367	0.215
	AG vs. GG	Random	96.31	≤0.001	1.406	0.482–4.096	0.624	0.533	0.901	0.570
	AA + AG vs. GG	Random	96.82	≤0.001	1.458	0.473–4.497	0.656	0.512	0.901	0.635
	AA vs. AG+ GG	Random	74.71	0.001	2.232	0.439–11.33	0.968	0.334	0.229	0.168
By Ethnicity
Caucasian	A vs. G	Fixed	13.29	0.316	1.136	0.816–1.581	0.756	0.449	0.296	0.321
	AA vs. GG	Fixed	48.02	0.146	1.616	0.401–6.510	0.675	0.500	0.296	0.043
	AG vs. GG	Fixed	0.00	0.785	1.080	0.740–1.576	0.397	0.691	0.296	0.354
	AA + AG vs. GG	Fixed	0.00	0.538	1.120	0.773–1.621	0.598	0.550	0.296	0.290
	AA vs. AG+ GG	Fixed	46.16	0.156	1.606	0.400–6.442	0.668	0.504	0.296	0.049
Asian	A vs. G	Random	98.11	≤0.001	2.066	0.321–13.300	0.764	0.445	1.000	0.440
	AA vs. GG	Random	85.37	0.001	6.219	0.211–183.489	1.058	0.290	1.000	0.904
	AG vs. GG	Random	97.52	≤0.001	3.199	0.538–19.018	1.279	0.201	1.000	0.632
	AA + AG vs. GG	Random	97.81	≤0.001	3.455	0.536–22.25	1.304	0.192	1.000	0.674
	AA vs. AG+ GG	Random	70.92	0.032	5.559	0.509–60.68	1.407	0.160	1.000	0.884
TNF-α -238 G > A
Overall	A vs. G	Fixed	0.00	0.452	1.009	0.641–1.587	0.038	0.970	1.000	0.411
	AA vs. GG	Fixed	0.00	1.000	0.384	0.015–9.550	−0.583	0.560	NA	NA
	AG vs. GG	Fixed	14.54	0.310	1.060	0.661–1.710	0.243	0.808	1.000	0.545
	AA + AG vs. GG	Fixed	0.796	0.365	1.036	0.648–1.657	0.148	0.882	1.000	0.497
	AA vs. AG+ GG	Fixed	0.00	1.000	0.360	0.015–8.942	−0.623	0.533	NA	NA

NA: Not Applicable.