Figure 1. Methods for probing and visualizing genome architecture.
a) Schematic of single-locus imaging in fixed cells using DNA fluorescence in situ hybridization (FISH)
b) General pipeline for a Hi-C genomics experiment
c-e) Live-cell technologies for visualizing single genomic loci including zinc fingers (ZFs, Panel C), transcription activator-like effectors (TALEs, Panel D), and CRISPR-Cas9 (Panel E)