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. Author manuscript; available in PMC: 2018 Jun 22.
Published in final edited form as: Ann Neurol. 2009 Sep;66(3):290–297. doi: 10.1002/ana.21732

Figure 4.

Figure 4

IFN-γ ELISpot assays for all three subjects. α-SG and control enhanced Green fluorescent protein (eGFP) peptide stimulation showed no increase in spot forming colonies (SFC) per million peripheral blood mononuclear cells (PBMCs) in any subject. In Subject 1 there was a very minimal IFN-γ response specific to Pool 2 of the AAV1 capsid exceeding our confidence limits for a negative response (>50 spot forming cells /million PBMCs) at days 14 and 43. ELISpot assays were negative for Subjects 2 and 3. (dpi = days post injection; red = α–SG; black = eGFP; blue = AAV1 capsid pool 1; green = AAV1 capsid pool 2; purple = AAV1 capsid pool 3).

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