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. 2018 Jun 22;13(6):e0199666. doi: 10.1371/journal.pone.0199666

Fig 7. NK-4 down-regulates secretion of TARC by NHDF stimulated with both IL-4 and TNF-α.

Fig 7

NHDF were stimulated with 10 ng/ml IL-4 and 5 ng/ml TNF-α in the presence or absence (control) of varying concentrations of NK-4, dexamethasone or FK-506 (A) for 48 h at 37°C. In experiments comparing NK-4 with suplatast tosilate (B), NHDF were exposed to test articles for 15 min before stimulation with IL-4 and TNF-α. TARC levels in the cultures of NHDF without stimulation were below detectable limits. Results are the means ± S.D. of triplicate cultures. Results are representative of three independent experiments with similar results. **p < 0.01 compared with control cultures.