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Reagents and conditions: (i) oxalyl chloride, DMF, 1,4-benzodioxane-6-carboxylic acid, DCM, then, 4-methyl-3-nitroaniline, pyridine, DCM, RT, then Pd/C (10%), H2 (1 atm), EtOH; (ii) NaH, RCH2OH, THF, 0 °C to reflux; (iii) n-BuLi, CO2(s), THF, −78 °C; (iv) HATU, DIPEA, DMF, RT.
