Table 2.

Descriptive statistics of miRNAs, mRNAs, and cytokines in sham-purified air and true-purified air scenarios for all subjects during the two intervention stages.

Variables	Sham-purified air						True-purified air
	Minimum	P25	Meana	P50	P75	Maximum	Minimum	P25	P50	Meana	P75	Maximum
miRNAsb
miR-21-5p	0.02	0.10	0.32	0.34	0.95	4.11	0.05	0.30	0.66	0.79	1.63	7.86
miR-26a-5p	0.06	0.13	0.24	0.21	0.34	2.28	0.02	0.12	0.28	0.37	0.55	8.02
miR-187-3p	0.01	0.02	0.05	0.03	0.09	0.49	0.01	0.03	0.13	0.14	0.28	7.27
miR-146a-5p	0.01	0.04	0.08	0.08	0.16	1.45	0.01	0.06	0.20	0.18	0.54	10.42
miR-19b-3p	0.04	0.08	1.61	5.59	19.64	51.85	0.02	0.09	1.21	1.74	15.76	46.72
miR-93-5p	0.06	0.14	0.33	0.38	0.72	2.89	0.04	0.11	0.27	0.33	0.59	2.13
miR-145-5p	0.01	0.02	0.08	0.07	0.25	1.14	0.01	0.03	0.14	0.10	0.36	17.4
miR-1-3p	0.01	0.02	0.07	0.06	0.23	1.88	0.01	0.06	0.22	0.19	0.49	11.70
miR-199a-5p	0.01	0.03	0.04	0.03	0.06	0.12	0.01	0.03	0.07	0.06	0.10	1.28
miR-4492	0.01	0.03	0.10	0.15	0.37	12.37	0.01	0.03	0.14	0.18	0.38	14.05
mRNAsb
IL1	0.06	0.19	0.43	0.41	0.64	22.26	0.05	0.15	0.27	0.21	0.40	6.75
IL6	0.22	1.88	2.92	2.72	4.45	67.97	0.18	1.08	1.59	1.35	2.92	35.56
TNF	0.17	0.39	0.62	0.50	0.86	11.61	0.17	0.25	0.44	0.44	0.58	6.86
TLR2	0.09	0.15	0.28	0.23	0.39	6.39	0.03	0.12	0.20	0.19	0.29	2.56
CD40LG	0.07	0.52	0.83	0.75	1.17	19.05	0.12	0.41	0.64	0.70	0.87	8.98
ICAM1	0.03	0.12	0.21	0.19	0.33	5.40	0.04	0.10	0.17	0.14	0.22	3.15
F3	0.08	0.25	0.51	0.39	0.62	30.10	0.09	0.16	0.35	0.25	0.66	2.89
SERPINE1	0.28	0.54	1.12	1.12	1.67	24.62	0.15	0.61	0.96	0.91	1.41	12.56
EDN1	0.16	0.92	1.30	1.52	2.03	9.20	0.09	0.30	0.66	0.66	1.24	10.16
ACE	0.09	0.51	0.88	0.86	1.10	32.24	0.11	0.34	0.67	0.71	1.25	31.44
Cytokines
IL-1 (ng/mL)	7	13	23	19	48	94	3	8	14	15	21	54
IL-6 (ng/mL)	1	49	88	116	203	623	1	38	59	81	173	443
$\text{TNF}-\mathrm{\alpha }$ (ng/mL)	15	43	57	55	76	149	10	37	44	50	58	143
TLR-2 (ng/mL)	0.2	0.5	0.7	0.7	1.0	2.7	0.1	0.4	0.5	0.6	0.8	2.8
CD40L (pg/mL)	84	130	184	202	235	935	21	131	167	182	234	418
ICAM-1 (ng/mL)	4	5	7	7	8	27	4	5	6	6	7	13
F3 (pg/mL)	37	53	82	68	113	394	28	49	76	66	107	419
PAI-1 (ng/mL)	60	105	120	124	146	209	24	92	113	116	140	215
ET-1 (pg/mL)	2	5	8	7	12	186	2	5	7	6	10	88
ACE-1 (ng/mL)	93	151	182	187	223	428	88	134	176	180	220	341

Note: ACE-1, angiotensin converting enzyme-1; CD40L, CD40 ligand; ET-1, endothelin-1; F3, tissue factor 3; ICAM-1, intercellular adhesion molecule-1; IL-1, interleukin-1; IL-6, interleukin-6; miRNA, microRNA; mRNA, messenger RNA; P, percentile; PAI-1, plasminogen activator inhibitor-1; TLR-2, toll-like receptor-2; $\text{TNF}-\mathrm{\alpha }$, tumor necrosis $\text{factor}-\mathrm{\alpha }$.

^aGeometric means.

^bCalculated using the relative quantifications formula ($2^{–\mathrm{\Delta }\mathrm{\Delta }\text{Cq}}$).