Table 3.

Percent changes (mean and 95% confidence intervals) in miRNAs, mRNAs, and circulating cytokines comparing the true-purified air scenario with the sham-purified air scenario.

Genes	Mean	95% CI	p-Value	FDR
miRNAs
miR-21-5p	133	76, 191	0.002	0.006
miR-26a-5p	15	$-34$, 64	0.542	0.773
miR-187-3p	143	81, 205	0.002	0.006
miR-146a-5p	111	53, 169	0.006	0.013
miR-19b-3p	6	$-87$, 99	0.895	0.895
miR-93-5p	7	$-37$, 52	0.725	0.805
miR-145-5p	58	$-21$, 137	0.180	0.300
miR-1-3p	148	74, 222	0.006	0.013
miR-199a-5p	76	41, 112	0.001	0.006
miR-4492	15	$-48$, 78	0.618	0.773
mRNAs
IL1	$-63$	$-102$, $-24$	0.010	0.025
IL6	$-74$	$-103$, $-46$	$<0.001$	0.002
TNF	$-38$	$-58$, $-18$	0.002	0.009
TLR2	$-44$	$-74$, $-14$	0.013	0.027
CD40LG	$-25$	$-51$, 0	0.073	0.102
ICAM1	$-26$	$-61$, 9	0.164	0.164
F3	$-61$	$-110$, $-12$	0.039	0.065
SERPINE1	$-22$	$-46$, 1	0.081	0.102
EDN1	$-87$	$-132$, $-42$	0.004	0.013
ACE	$-29$	$-68$, 9	0.161	0.164
Cytokines
IL-1	$-56$	$-88$, $-23$	0.006	0.021
IL-6	$-55$	$-105$, $-4$	0.064	0.128
$\text{TNF}-\mathrm{\alpha }$	$-5$	$-26$, 17	0.658	0.731
TLR-2	$-2$	$-26$, 22	0.853	0.853
CD40L	$-19$	$-35$, $-2$	0.039	0.097
ICAM-1	$-8$	$-28$, 13	0.466	0.583
F3	$-22$	$-31$, $-13$	$<0.001$	0.001
PAI-1	$-6$	$-17$, 6	0.339	0.485
ET-1	$-21$	$-35$, $-8$	0.006	0.032
ACE-1	$-4$	$-12$, 4	0.306	0.484

Note: ACE-1, angiotensin converting enzyme-1; CD40L, CD40 ligand; CI, confidence interval; ET-1, endothelin-1; F3, tissue factor 3; FDR, false discovery rate; ICAM-1, intercellular adhesion molecule-1; IL-1, interleukin-1; IL-6, interleukin-6; miRNA, microRNA; mRNA, messenger RNA; PAI-1, plasminogen activator inhibitor-1; TLR-2, toll-like receptor-2; $\text{TNF}-\mathrm{\alpha }$, tumor necrosis $\text{factor}-\mathrm{\alpha }$.