Table 1.

Coactivator steroid receptor coactivators (SRCs) and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) in the $\text{ligand}–\text{ER}\mathrm{\alpha }$ complex by Microarray Assay for Real-Time Coregulator-Nuclear receptor Interaction (MARCoNI) assay.

Coactivators	Peptides	Peptide sequences	Motifs	Relative binding valuesa
				E2	BPA	BPAF	BPS
SRC1	NCOA1_737_759	ASKKKESKDHQLLRYLLDKDEKD	LxxLL749	47.5	2.5	—	1.4
	NCOA1_620_643	SDGDSKYSQTSHKLVQLLTTTAEQ	LxxLL633	45.1	2.0	—	3.6
	NCOA1_1421_1441	TSGPQTPQAQQKSLLQQLLTE	LxxLL1435	5.6	—	—	1.3
	NCOA1_677_700	PSSHSSLTERHKILHRLLQEGSPS	LxxLL690	5.5	—	—	1.6
SRC2	NCOA2_628_651	GQSRLHDSKGQTKLLQLLTTKSDQ	LxxLL641	12.8	1.3	—	1.9
	NCOA2_677_700	STHGTSLKEKHKILHRLLQDSSSP	LxxLL690	9.7	—	—	1.7
	NCOA2_733_755	EPVSPKKKENALLRYLLDKDDTK	LxxLL745	8.6	—	—	1.4
SRC3	NCOA3_609_631	KKKGQGVIDKDSLGPLLLQALDG	LxxLL113	21.1	—	—	2.4
	NCOA3_609_631_C627S	QRGPLESKGHKKLLQLLTCSSDD	LxxLL621	13.1	—	—	1.7
	NCOA3_725_747	MHGSLLQEKHRILHKLLQNGNSP	LxxLL685	6.3	—	—	1.2
	NCOA3_673_695	QRGPLESKGHKKLLQLLTSSSDD	LxxLL621	5.8	—	—	—
	NCOA3_104_123_N-KKK	HGSQNRPLLRNSLDDLLGPPSNA	LxxLL1041	2.5	—	1.5	—
$\text{PGC}1\mathrm{\alpha }$	PRGC1_130_155	DGTPPPQEAEEPSLLKKLLLAPANTQ	LxxLL144	5.2	1.1	—	1.9
	PRGC1_134_154	PPQEAEEPSLLKKLLLAPANT	LxxLL144	5.8	0.9	—	1.5
$\text{PGC}1\mathrm{\beta }$	PRGC2_146_166	PAPEVDELSLLQKLLLATSYP	LxxLL156	7.1	—	—	1.5
	PRGC2_338_358	AEFSILRELLAQDVLCDVSKP	LxxLL343	6.0	—	—	—

Note: —, no binding; BPA, bisphenol A; BPAF, bisphenol AF; BPS, bisphenol S; E2, estradiol.

^aRelative binding value shows each peptide binding relative to the control, 2% DMSO. (Cutoff: binding value, $>50$; relative binding, $>1$; p-value, $<0.05$.)