Table 3.

Nominally significant associations of reproducible molecular features with baseline total water arsenic and baseline total urinary arsenic.

Metabolite	ICC (95% CI)	Water arsenic			Urinary arsenic
		$\mathrm{\beta }$a (95% CI)	Raw p-value	FDR p-value	$\mathrm{\beta }$a (95% CI)	Raw p-value	FDR p-value
Aminoethanol	0.60 (0.46, 0.70)	0.48 (0.06, 0.89)	0.025	0.11	0.50 (0.09, 0.91)	0.018	0.07
$\mathrm{\beta }-\text{Amino}$ isobutyric acid	0.68 (0.57, 0.77)	$-0.02$ ($-0.05$, 0.01)	0.211	0.39	$-0.03$ ($-0.06$, $-0.00$)	0.043	0.11
Citric acid	0.62 (0.49, 0.72)	$-0.03$ ($-0.05$, 0.00)	0.051	0.17	$-0.03$ ($-0.05$, $-0.00$)	0.048	0.12
1,2-Dithiane-4,5-diol	0.70 (0.59, 0.78)	0.35 (0.09, 0.62)	0.010	0.07	0.58 (0.34, 0.83)	$<0.001$	0.001
Ethanedioic acid	0.67 (0.56, 0.76)	$-0.00$ ($-0.01$, 0.00)	0.200	0.38	$-0.00$ ($-0.01$, $-0.00$)	0.049	0.12
3-Hydroxyisovaleric acid	0.63 (0.51, 0.73)	$-0.02$ ($-0.04$, $-0.00$)	0.022	0.11	$-0.02$ ($-0.04$, 0.00)	0.052	0.12
Glycine	0.60 (0.47, 0.71)	$-0.09$ ($-0.19$, 0.01)	0.072	0.20	$-0.11$ ($-0.20$, $-0.01$)	0.031	0.09
Indole-3-acetic acid	0.61 (0.48, 0.71)	$-0.04$ ($-0.09$, 0.00)	0.060	0.17	$-0.05$ ($-0.09$, $-0.00$)	0.035	0.10
l-Threonine	0.60 (0.46, 0.70)	$-0.13$ ($-0.22$, $-0.04$)	0.006	0.05	$-0.15$ ($-0.24$, $-0.06$)	0.001	0.02
Phosphoric acid	0.67 (0.55, 0.76)	1.05 (0.13, 1.96)	0.025	0.11	1.25 (0.35, 2.15)	0.007	0.04
Pyroglutamic acid	0.64 (0.51, 0.73)	$-0.47$ ($-0.93$, $-0.01$)	0.047	0.16	$-0.68$ ($-1.13$, $-0.23$)	0.003	0.03
(R*,S*)-3,4-Dihydroxybutanoic acid	0.61 (0.48, 0.72)	$-0.09$ ($-0.16$, $-0.02$)	0.016	0.10	$-0.09$ ($-0.17$, $-0.02$)	0.010	0.04
Serine	0.63 (0.51, 0.73)	$-0.18$ ($-0.37$, 0.02)	0.070	0.20	$-0.21$ ($-0.40$, $-0.01$)	0.035	0.10
Succinic acid	0.63 (0.50, 0.73)	$-0.02$ ($-0.04$, $-0.01$)	0.003	0.04	$-0.02$ ($-0.04$, $-0.01$)	$<0.001$	0.02
Uracil	0.63 (0.50, 0.73)	$-0.05$ ($-0.11$, 0.01)	0.127	0.28	$-0.07$ ($-0.13$, $-0.01$)	0.031	0.09
Uric acid	0.64 (0.51, 0.73)	2.56 (0.39, 4.74)	0.022	0.11	1.27 ($-0.93$, 3.47)	0.255	0.35

^aCoefficient from linear regression model indicates difference in peak intensity of urinary metabolites in relation to per 1-SD increase in water arsenic ($51.3\mathrm{\mu }\mathrm{g}/\mathrm{L}$) and per 1-SD increase in urinary arsenic ($173.4\mathrm{\mu }\mathrm{g}/\mathrm{g}$ creatinine), adjusting for sex, age, and cohort memberships.