Table 3.
CpG annotations | Meta-analysis | NHBCS () | RICHS () | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CpG ID | Ch. | Genomic position | Gene | Regulatory feature | p-Value | FDR | p-Value | p-Value | |||
cg16034168a | 1 | 6336711 | ACOT7 | Body | 0.32 | 0.171 | 0.32 | 0.32 | |||
cg24000528 | 2 | 177013630 | MIR10B | TSS1500 | 0.16 | 0.182 | 0.18 | 0.16 | |||
cg24696183 | 11 | 2891360 | KCNQ1DN | Body | 0.171 | ||||||
cg23193177 | 11 | 45717613 | - | - | 0.24 | 0.171 | 0.22 | 0.27 | |||
cg15345741a | 14 | 103674333 | - | - | 0.25 | 0.04 | 0.25 | 0.24 | |||
cg06100161 | 15 | 60987894 | RORA | Body | 0.20 | 0.171 | 0.12 | 0.28 | |||
cg03917020 | 16 | 85285139 | - | - | 0.14 | 0.174 | 0.13 | 0.14 | |||
cg02600679 | 16 | 88832700 | PIEZO1 | Body | 0.25 | 0.171 | 0.17 | 0.34 | |||
cg04267691 | 17 | 9862752 | GAS7 | Body; 5'UTR | 0.18 | 0.178 | 0.12 | 0.24 | |||
cg10517535 | 17 | 9929698 | GAS7 | Body; TSS200 | 0.31 | 0.177 | 0.16 | 0.59 | |||
cg03762242a | 17 | 9940004 | GAS7 | Body; 5'UTR | 0.23 | 0.171 | 0.20 | 0.26 | |||
cg16768966a | 17 | 9940227 | GAS7 | Body; TSS200 | 0.31 | 0.171 | 0.23 | 0.42 | |||
cg10618704 | 17 | 9940970 | GAS7 | TSS1500; Body | 0.36 | 0.174 | 0.24 | 0.54 | |||
cg11851174 | 17 | 17712609 | RAI1 | Body | 0.19 | 0.171 | 0.20 | 0.18 | |||
cg19944656 | 17 | 76876040 | TIMP2 | Body | 0.18 | 0.171 | 0.17 | 0.18 | |||
cg11707084a | 19 | 48345263 | CRX | 3'UTR | 0.22 | 0.04 | 0.23 | 0.22 | |||
cg03566291 | 21 | 44831040 | - | - | 0.23 | 0.201 | 0.21 | 0.29 |
Note: Ch., chromosome; CpG, cytosine-phosphate-guanine methylation site; FDR, false discovery rate adjusted p-value; NHBCS, New Hampshire Birth Cohort; RICHS, Rhode Island Child Health Study; TSS200, within 200 bp of the transcriptions start site; TSS1500, within 1500 bp of the transcription start site; UTR, untranslated region.
CpG Sites that yielded meta-analysis in models before and after heterogeneity adjustments.