Table 2.
INHBA expression and other important clinicopathological parameters in esophageal squamous cell carcinoma
| Variables | Cases (n=239) | INHBA expression
|
P-valuea | |
|---|---|---|---|---|
| Low (n=66, %) | High (n=173, %) | |||
| Age, yearsb | 0.504 | |||
| ≤58 | 127 | 39 (30.7) | 88 (69.3) | |
| >58 | 112 | 30 (26.8) | 82 (73.2) | |
| Sex | 0.634 | |||
| Female | 64 | 17 (26.6) | 47 (73.4) | |
| Male | 175 | 52 (28.0) | 123 (72.0) | |
| Tumor location | 0.171 | |||
| Upper | 12 | 4 (33.3) | 8 (66.7) | |
| Middle | 163 | 41 (25.2) | 122 (74.8) | |
| Lower | 64 | 24 (37.5) | 40 (62.5) | |
| Histological gradec | 0.1 | |||
| Grade 1 | 58 | 23 (39.7) | 37 (60.3) | |
| Grade 2 | 154 | 38 (24.7) | 116 (75.3) | |
| Grade 3 | 27 | 8 (29.6) | 19 (70.4) | |
| pT statusc | 0.458 | |||
| pT 1 | 6 | 3 (50.0) | 3 (50.0) | |
| pT 2 | 55 | 15 (27.3) | 40 (72.7) | |
| pT 3 | 175 | 51 (29.1) | 124 (70.9) | |
| pT 4 | 3 | 0 (0.00) | 2 (100.0) | |
| N categories | 0.026 | |||
| Negative | 129 | 45 (34.9) | 84 (65.1) | |
| Positive | 110 | 24 (21.8) | 86 (78.2) | |
| TNM stage | 0.172 | |||
| Stage 1 | 9 | 3 (33.3) | 6 (66.7) | |
| Stage 2 | 138 | 46 (33.3) | 92 (66.7) | |
| Stage 3 | 91 | 20 (22.0) | 71 (78.0) | |
Notes:
a
Probability value of <0.05 indicates statistical significance shown in bold. Probability values were calculated by Pearson’s χ2 test.
b
Age was divided according to the median age of 58 years.
c
The grading and histopathology staging of ESCC specimens was based on the World Health Organization classification published in 2009.25
Abbreviation: ESCC, esophageal squamous cell carcinoma.