Table 6. Overview of recent clinical trials testing genistein with respect to diabetic and inflammatory markers .

Treatment group	Dose; duration	Ref.	Effect of genistein
23 patients with prostate cancer	30 mg genistein/d; 3–6 w	(123)	Reduction of blood cholesterol
43 healthy, ob, pmp females	60.8 mg genistein (t.w. 16 mg daidzein+3.2 mg glycitein)/d; 6 m	(124)	Enhancement of adiponectin serum levels
71 pmp osteopenic females	54 mg genistein/d; 24/36 m	(125)	Reduction of fasting glucose and insulin, HOMA-IR, fibrinogen and homocysteine after 24/36 months of treatment
30 pmp normo- and hyperinsulinemic females	54 mg genistein/d; 24 w	(126)	Reduction of fasting glucose in normoinsulinemic patients; reduction in fasting insulin, fasting C-peptide; improvement of HDL levels
32 healthy, pmp females	64 mg genistein (t.w. 63 mg daidzein and 34 mg glycitein)/d; 12 w	(127)	Enhancement in serum adiponectin levels; no effect on metabolic parameters
25 pmp females	2 mg genistein (t.w. 4.8 mg daidzein)/d; 6 m	(128)	No significant effect

Ob: obese; pmp: post-menopausal; d: days; w: weeks; m: months; t.w.: together with