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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Trends Biochem Sci. 2018 Apr 30;43(7):499–516. doi: 10.1016/j.tibs.2018.03.007

Figure 2.

Figure 2

Atomistic view of liquid-liquid phase separation (LLPS) for γII-crystallin. (a) Snapshot of a transient bonding network. The γII-crystallin molecule at the center presently is in contact with four other molecules (numbered 1-4); four molecules (numbered 5-8) further into the background and in contact with the bonding partners of the central molecule are also shown, but bonding partners of the central molecule in the foreground are not displayed. Molecules are displayed as surface, with acidic (Asp/Glu), basic (Arg/Lys), and hydrophobic (Leu/Ile/Val/Met/Phe) residues in blue, red, and green respectively. (b) Calculated LLPS coexistence curve for γII-crystallin. Reproduced from ref [46].