Skip to main content
. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Biol Psychiatry. 2018 Feb 3;84(1):9–17. doi: 10.1016/j.biopsych.2018.01.012

Figure 1.

Figure 1

Mitochondrial health index (MHI) and mitochondrial profiling in human leukocytes. (A) Schematic of a human peripheral blood leukocyte and its mitochondria. The internal components of the mitochondrial respiratory chain (complexes I–V), the tricarboxilic acid ([TCA], also Krebs) cycle, and the mitochondrial genome (mtDNA) are shown in the inset with the inner mitochondrial membrane. (B) Mathematical integration of two nuclear DNA (nDNA)-encoded components (left), and mtDNA-related components (right) into the MHI. (C) Frequency distribution of MHI in the study sample. See Table 3 for statistics. (D) Correlation matrix generated by unsupervised clustering between enzymatic activities, calculated ratios, mtDNA copy number (mtDNAcn), and respiratory chain complexes protein levels. Three major clusters of correlated variables are highlighted. (E) Results from partial least square discriminant analysis model showing rank-ordered variables based on their variable importance in projection (VIP) scores for the first component of the full model; n = 89 to 91 for all. VIP values >1 are considered significant. ATP, adenosine triphosphate; COX, cytochrome c oxidase; CS, citrate synthase; Mito, mitochondrial; SDH, succinate dehydrogenase.