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. 2018 Jun 22;9:2454. doi: 10.1038/s41467-018-04465-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Pharmacokinetic model of the disposition of orally and intravenously administered KBU2046. Schematic depiction of the three-compartment pharmacokinetic (PK) model used determine plasma KBU2046 concentration versus time relationships after intravenous (IV) or oral administration. The rate constants k_in and k_out determine the fraction of the drug absorbed after oral administration (bioavailability, F_oral). Drug enters the central compartment (central volume, V_C) from which it equilibrates with the rapidly equilibrating (fast volume, V_F) and slowly equilibrating (slow volume, V_S) peripheral compartments at rates dictated by their respective intercompartmental clearances (Ci_F and Cl_S). Drug is eliminated from VC by elimination clearance (Cl_E).