Table 2.
Diagnostic performance of perfusion parameters from DCE-MRI to predict pathologic complete response.
| Cut-off value* | non-CR (n = 61) | CR (n = 13) | Sensitivity (99.8% CI**) | Specificity (99.8% CI**) | AUC (99.8% CI**) | |
|---|---|---|---|---|---|---|
| 2D analysis of BP CL | ||||||
| Ktrans | ≥0.03 | 16 | 8 | 0.615 (0.190–0.940) | 0.738 (0.560–0.915) | 0.683 (0.425–0.941) |
| Kep | ≥0.21 | 12 | 6 | 0.462 (0.025–0.795) | 0.803 (0.643–0.964) | 0.627 (0.331–0.924) |
| Ve | ≥0.20 | 11 | 6 | 0.462 (0.025–0.795) | 0.820 (0.664–0.975) | 0.629 (0.332–0.925) |
| 3D histogram analysis of tumor | ||||||
| Ktrans | ||||||
| 25th perc | ≥0.11 | 29 | 9 | 0.692 (0.288–1.000) | 0.525 (0.323–0.726) | 0.610 (0.335–0.885) |
| 50th perc | ≥0.22 | 24 | 9 | 0.692 (0.288–1.000) | 0.607 (0.409–0.804) | 0.624 (0.305–0.943) |
| 75th perc | ≥0.34 | 19 | 9 | 0.692 (0.288–1.000) | 0.689 (0.501–0.876) | 0.612 (0.285–0.938) |
| mean | ≥0.24 | 23 | 9 | 0.692 (0.288–1.000) | 0.623 (0.427–0.819) | 0.605 (0.287–0.924) |
| kurtosis | ≤−0.92 | 28 | 4 | 0.308 (0.000–0.616) | 0.541 (0.340–0.742) | 0.502 (0.235–0.769) |
| skewness | ≤0.52 | 38 | 12 | 0.923 (0.690–1.000) | 0.377 (0.181–0.573) | 0.647 (0.388–0.905) |
| Kep | ||||||
| 25th perc | ≥0.14 | 50 | 13 | 1.000 (1.000–1.000) | 0.180 (0.025–0.336) | 0.546 (0.267–0.825) |
| 50th perc | ≥0.51 | 22 | 8 | 0.615 (0.190–0.940) | 0.639 (0.445–0.833) | 0.575 (0.257–0.893) |
| 75th perc | ≥0.94 | 9 | 5 | 0.385 (0.000–0.710) | 0.852 (0.709–0.996) | 0.571 (0.241–0.902) |
| mean | ≥0.55 | 24 | 8 | 0.615 (0.190–0.940) | 0.607 (0.409–0.804) | 0.574 (0.250–0.897) |
| kurtosis | ≥4.53 | 2 | 2 | 0.154 (0.000–0.395) | 0.967 (0.895–1.000) | 0.508 (0.212–0.804) |
| skewness | <0.82 | 41 | 10 | 0.769 (0.400–1.000) | 0.328 (0.138–0.518) | 0.535 (0.267–0.802) |
| Ve | ||||||
| 25th perc | ≤0.43 | 31 | 9 | 0.692 (0.288–1.000) | 0.492 (0.290–0.694) | 0.472 (0.243–0.702) |
| 50th perc | ≤0.52 | 28 | 9 | 0.692 (0.288–1.000) | 0.541 (0.340–0.742) | 0.487 (0.236–0.738) |
| 75th perc | ≤0.61 | 30 | 8 | 0.615 (0.190–0.940) | 0.508 (0.306–0.710) | 0.484 (0.223–0.745) |
| mean | ≤0.53 | 29 | 9 | 0.692 (0.288–1.000) | 0.525 (0.323–0.726) | 0.494 (0.244–0.745) |
| kurtosis | ≤0.28 | 40 | 6 | 0.462 (0.025–0.795) | 0.344 (0.152–0.536) | 0.449 (0.183–0.715) |
| skewness | ≤−0.10 | 23 | 9 | 0.692 (0.288–1.000) | 0.623 (0.427–0.819) | 0.641 (0.375–0.907) |
*Optimal cut off point was obtained from Youden index on ROC curve perc, percentile.
**Confidence interval use a Bonferroni corrected (1–0.05/30) confidence level.