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. 2018 Jun 22;8:9511. doi: 10.1038/s41598-018-27864-6

Figure 3.

Figure 3

GRAMD1B inhibition promotes cell migration in breast cancer cells. (a-a’) Transwell migration assay shows an increase in cell migration on Gramd1b knockdown. (Scale bar = 100 μm). Data is represented as mean ± SEM of n = 3. (b-b’) Wound healing assay confirms the inhibitory effects of GRAMD1B on cell migration. Data is represented as mean ± SEM of n = 3. (c,d) qRT-PCR and Western blot analyses show a significant induction of the Rho GTPase Rac1, RhoA and Cdc42 at both mRNA and protein levels. Data is represented as mean ± SEM of n = 3. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.