. 2018 Jun 22;8:9539. doi: 10.1038/s41598-018-27687-5

Table 2.

MIC values (µg/ml) of multidrug transporter gene deletion mutants compared to wildtype M. smegmatis.

	ABC								MATE	MFS							SMR				wild type
	ΔMSMEG_0017/0018	ΔMSMEG_1502/1504	ΔMSMEG_1642	ΔMSMEG_4380	ΔMSMEG_5008/5009	ΔMSMEG_5075/5076	ΔMSMEG_5659/5660	ΔMSMEG_6509/6510	ΔMSMEG_2631	ΔMSMEG_3563	ΔMSMEG_3705	ΔMSMEG_5046	ΔMSMEG_5187	ΔMSMEG_5670	ΔMSMEG_6225 (LfrA)	ΔMSMEG_6390	ΔMSMEG_3670	ΔMSMEG_3672	ΔMSMEG_3815	ΔMSMEG_6221	wild type
Isoniazid	200	200	200	200	200	200	200	200	200	200	200	200	200	200	200	200	200	200	200	200	200
Rifampicin	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8
Ethambutol	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10	>10
Streptomycin	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25
Kanamycin	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5
Ofloxacin	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6
Ciprofloxacin	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6	0.6
Ampicillin	125	125	125	125	125	125	125	125	125	125	125	125	125	125	125	125	125	125	125	125	125
Chloramphenicol	32	32	32	32	32	32	32	32	32	32	32	32	32	32	32	32	32	32	32	32	32
Tetracycline	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2	1.2
Vancomycin	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5	2.5
Novobiocin	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16
Ethidium	6	6	6	6	6	6	6	6	6	6	3	6	6	6	0.75	6	6	6	6	6	6

The transporters are sorted according to transporter families. MIC determinations were carried out as technical duplicates. In the rare event that the two values differed, the higher of the two MIC values was reported.