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. 2018 Jun 22;8:9528. doi: 10.1038/s41598-018-27809-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of flavones with furan B-ring on human platelet activation. (A) Chemical structures of the flavones, F-3, TF-3, CYC-3 and TCYC-3. (B) Representative traces displaying the level of aggregation obtained when human isolated platelets were treated (for 5 minutes) with a vehicle control [0.1% (v/v) DMSO] or various concentrations of flavones, F-3, TF-3, CYC-3 and TCYC-3 (3.125–100 μM) and 0.5 μg/mL CRP-XL. (C) Bar graphs display the percentage of aggregation obtained in the presence and absence of diverse concentrations of flavones, F-3, TF-3, CYC-3 and TCYC-3. The data were normalised by considering the maximum aggregation observed for the vehicle control at 5 minutes as 100%, and the level of inhibition in flavone and its derivatives-treated platelet samples was calculated accordingly. Cumulative data denote mean ± S.D. (n = 3). The p values displayed (*p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.001) are as analysed by one-way ANOVA using Graphpad Prism.