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. 2018 Jun 22;8:9513. doi: 10.1038/s41598-018-27753-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In ES2, OVCAR8 and A2780 cancer stem CD133⁺ cells command resistance to hypoxia and carboplatin. CD133 expression levels in a drug-free environment and upon carboplatin exposure for (A) ES2 cells, (B) OVCAR3 cells, (C) OVCAR8 cells, (D) A2780 parental cells and (E) A2780 cisR cells in the first and in the second cycles of treatments. N – Normoxia; NC – Normoxia supplemented with cysteine; H – Hypoxia; HC – Hypoxia supplemented with cysteine. Results are shown as mean ± SD. Asterisks represent statistical significance among the first and the second cycle within the same treatment. *p < 0.05, **p < 0.01, ***p < 0.001 (One-way ANOVA with post hoc Tukey tests).