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. 2018 Jun 22;8:9531. doi: 10.1038/s41598-018-27739-w

Figure 1.

Figure 1

PROX1 and MMP14 expressions are inversely correlated. (a) Representative image of a KS section from an AIDS patient stained with MMP14 (green) and Prox1 (magenta) specific antibodies. Nuclei were counterstained with Hoechst 33342. (b) MMP14 and Prox1 signal intensities for each cell were quantified from 3 images/section of 10 different patients. Each dot represents a cell and the different colours represent the different patients. (c) 57 specimens from TMA were stained as in (a), representative images are shown for one benign hyperplasia (left) and one papillary thyroid cancer (right). White arrows indicate cells with Prox1 cytoplasmic staining. (d) Transcript levels of Prox1 and MMP14 in different tissues/organs derived from FANTOM5 database. Tags per million for MMP14 (Blue) and Prox1(red) are shown for each tissue/organ. Pearson´s correlation coefficient (r): −0.4515. Significance of the correlation p = 0.0065.