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. 2018 Jun 22;8:9554. doi: 10.1038/s41598-018-27900-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GO analysis of expanded co-IP proteins from S. cerevisiae and S. pombe. (a) Cellular compartment GO-derived terms (see Methods) were used to classify the cellular localization of expanded polyQ-associated group co-IP identifications; S. cerevisiae (red) and S. pombe (teal). Htt-97Q and Htt-103Q expanded polyQ-associated group co-IP identifications. The statistical significance indicated by *P < 0.05, calculated by Fisher’s exact test. (b) Cellular compartmentalization analysis of GO-derived terms used to classify the cellular localization of S. cerevisiae (top) and S. pombe (bottom). Statistical significance is relative to the expanded polyQ non-enriched group for each species. (c) GO Slim biological process enrichment analysis of Htt-97Q and Htt-103Q expanded polyQ-associated group co-IP identifications in S. cerevisiae (red) and S. pombe (teal). GO Slim terms related to biological function that overlapped between the two species were chosen for the analysis. The Y-axis shows the gene ontology terms in S. cerevisiae and S. pombe. The X-axis shows the enrichment ratio for each gene ontology term in S. cerevisiae and S. pombe. The dashed line indicates an enrichment ratio equals to 1. The statistical significance was indicated by *P < 0.05; calculated by the Fisher’s exact test.