Table 1.

Datasets used for Biostatistical Analyses.

Analyses performed	Dataset
Coiled-coil motif analysis	European Bioinformatics Institute website (http://www.ebi.ac.uk/reference_proteomes)
Zinc finger motif analysis	SCOP database (http://scop.mrc-lmb.cam.ac.uk/scop/)
Prion-like domain analysis	86
PolyQ analysis	Uniprot website (http://www.uniprot.org).
Essentiality analysis	Yeast Deletion Project (http://www-sequence.stanford.edu/group/yeast_deletion_project)
Gene Ontology analysis	Gene ontology website (http://geneontology.org/)
Protein domain annotation analysis	European Bioinformatics Institute website (http://pfam.xfam.org)
Htt toxicity analysis	38,40–42.
Disordered proteins analysis	DisProt (http://www.disprot.org)