Table 1.
Effect of GAL-1 treatment on weight loss and renal function induced by IR injury.
| Parameter | Group | |||
|---|---|---|---|---|
| SHAM | IR | IR + DEXA | IR + GAL-1 | |
| Weight loss (g) | −18.3 ± 10.6 | −11.7 ± 32.1 | −28.8 ± 18.2 | −38.0 ± 32.2 |
| Plasma creatinine (mg/dL) | 0.60 ± 0.12 | 2.47 ± 2.37++ | 0.65 ± 0.12 | 0.50 ± 0.07 |
| Creatinine clearance (mL/min/100 g) | 0.29 ± 0.13 | 0.16 ± 0.18+ | 0.35 ± 0.07 | 0.44 ± 0.17 |
| Urinary output (mL/24 h) | 12.2 ± 2.4 | 7.3 ± 3.0** | 14.3 ± 1.9 | 11.8 ± 3.2 |
| Sodium excretion fraction (%) | 0.22 ± 0.04 | 0.54 ± 0.20*** | 0.19 ± 0.05 | 0.21 ± 0.05 |
| Potassium excretion fraction (%) | 39.4 ± 14.7 | 65.6 ± 32.0* | 29.0 ± 7.0 | 32.8 ± 8.9 |
| BUN (mg/dL) | 18.0 ± 2.7 | 46.0 ± 24.9† | 27.0 ± 6.7 | 21.6 ± 2.8+ |
| TBARS (mMol/L) | 112.6 ± 19.1$ | 155.5 ± 24.9 | 207.5 ± 19.0 | 174.7 ± 12.6 |
| KIM-1 (pg/mL) | 213.5 ± 76.2 | 982.9 ± 96.7# | 943.9 ± 117.0# | 814.9 ± 43.7 |
aData represent the mean ± SD. N = 6 rats.
bThe IR group showed a reduction in renal function in comparison with the SHAM, DEXA or GAL-1-treated IR groups, as detected by the analysis of different renal parameters. No difference in weight loss was observed among groups (p > 0.05). One-way ANOVA or Kruskal-Wallis test.
+p < 0.05 and ++p < 0.01, IR vs IR + GAL-1.
*p < 0.05, **p < 0.01 and ***p < 0.001, IR vs all groups.
†p < 0.05, IR vs SHAM.
$p < 0.05, SHAM vs all groups.
#p < 0.05, IR and IR + DEXA vs SHAM.